The papers were filed in Los Angeles County Courts on August 13, according to The Blast, who cited the legal documents.
The Hollywood couple had been married for 19 years and have an 18-year-old daughter together, named Stella.
The move comes just weeks after the couple announced their separation on social media on July 3, shocking fans.
Sharing the same image, the 58-year-old Marvel star said the pair were “totally crying” as they shared the coordinated announcement on Instagram.
“After 19 years together, we separated in January, knowing we’d always be a family who loves, values and cares for each other,” they captioned the post.
“We recently made the difficult decision to divorce, but we remain close and are deeply grateful for the life we’ve shared and the wonderful daughter we’ve raised.”
While Gregg is best known now for his role in Agents of S.H.I.E.L.D and Grey, 60, is best known for the 80s cult classic Dirty Dancing, the couple have shared the screen a few times over the years.
In 2006 they both appeared in The Road to Christmas and earlier this year they starred in an episode of The Conners, playing a married couple looking to shake up their marriage.
Grey and Gregg began dating in 2000 and married in July 2001, welcomed their daughter in December that year.